Basic Information
VIS ID
TVIS10004735
Fusion event
HBV-chr5 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2177
Orient
+
Integrated sequence
CTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATA| |TGGGCCTAAAAATCAGACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGAAGAGAAACTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGAT
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
8082001/8081888 (Hg38)
End
8082001/8081888 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-4277/Upstream/1253967; hsa-mir-10397/Downstream/379037;
Nearest TSS
ENST00000502646/Upstream/157596; ENST00000605918/Downstream/363647;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/212161, chr5-CpG: 88/Downstream/375431
Nearby gene
LOC102723339(-7262) ;
Upstream sequence
ATATATTTTCCTTTCCACTATTTTTCTTTCATCAACATAACCTCAAATCAATATTATTATTTTTCTTCTTTTACCTCACTGCAGACCAGACTTTCCCTTG
Downstream sequence
CCTTTGATGGAAGATGTAAGGAGGTGGGCCTGTGTTGAAGCCCTCCTGAGTATGGCTACTGTTCCTATCGGCCTATGACTAGAGAAGCCCAGGAACTAAC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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