EYS _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004739
Fusion event
HBV-EYS integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1805
Orient
-
Integrated sequence
CTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr6
Cytoband
q12
Reference genome
GRCh37/hg19
Start
65785893/65076000 (Hg38)
End
65785893/65076000 (Hg38)
Orient
-
Location type
Intron
Target gene
EYS
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-510-3p ; hsa-mir-376a-5p ; hsa-mir-4680-5p ; hsa-mir-494-3p
Nearest miRNA
hsa-mir-10398/Upstream/7685788; hsa-mir-10524/Downstream/6300960;
Nearest TSS
ENST00000381078/Upstream/362665; ENST00000449928/Downstream/226937;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1439440, chr6-CpG: 22/Downstream/225360
Upstream sequence
tcaggaccctgtgatgattgcattaactgcacaaattgtttgtagagcatgtgtgtttgaacaatatgaaatctgggcaccttgaaaaaagaacaggata
Downstream sequence
GTTGGATTTGAAAAAAACAGGAAGTTACTTTACAGTCCAAATGACAACTACATAATTTAATGATAAGAGGTTTGTAAAACCACATTTTATTTTTGCTGGA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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