DENND2A _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004750
Fusion event
HBV-DENND2A integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
559
Orient
-
Integrated sequence
TATGTTGCCCGTTTGTCCTCTACTTCCAGGAACATCAACTACCAGCACGGGACCATGCAAGACCTGCACGATTCCTGCTCAAGGAACCTCTATGTTTCCC| |TCTTGTTGCTGTACAAAACCTTCGGACGGAAACTGCACTTGTATTCCCATCCCATCATCCTGGGCTTTCGCAAGATTCCTATGGGAGTGGGCCTCAGTCC
Host Sequence
Chromosome
chr7
Cytoband
q34
Reference genome
GRCh37/hg19
Start
140300651/140600851 (Hg38)
End
140300651/140600851 (Hg38)
Orient
+
Location type
Intron
Target gene
DENND2A
miRNAs that regulate target gene
hsa-mir-185-5p
Nearest miRNA
hsa-mir-10399/Upstream/1556694; hsa-mir-11400/Downstream/1873676;
Nearest TSS
ENST00000635602/Upstream/45138; ENST00000498423/Downstream/1661;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/121184, chr7-CpG: 135/Downstream/39346
Upstream sequence
tttttaaaactcgtttgttgaaaagtaagacacaaacatacacattagcctagacctacacagtcaggataatccttatcactgtcttccacctctatat
Downstream sequence
CAGATTTTATttttaagcattaacatgctttattatttaatgtgttattttaacgttataaaatattcacagtgcgtgcatccatatgtataaatgagga
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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