Basic Information
VIS ID
TVIS10004752
Fusion event
HBV-PLPPR1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1284
Orient
-
Integrated sequence
TGCTGACGCAACCCCCACTGGATGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTGGCTCCTCTGCCGATCCATACTGCGGAACTCCTA| |GCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCAAAACTTATCGGGACTGACAACTCTGTTGTCCTCTCTCGGAAATACACCTCCTTCCCATGGCTGCTCG
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
103815897/101053615 (Hg38)
End
103815897/101053615 (Hg38)
Orient
+
Location type
Intron
Target gene
PLPPR1
Nearest miRNA
hsa-let-7a-1/Upstream/2824398; hsa-mir-12126/Downstream/5547313;
Nearest TSS
ENST00000422679/Upstream/24906; ENST00000494890/Downstream/77907;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/24133, chr9-CpG: 49/Downstream/344956
Junction sequence
G
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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