Fusion event
HBV-chr9 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATC| |CCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTGAGTGGCAAACTCCCTCCTTTCCTAACATTCATT
End
118624404/115862125 (Hg38)
Nearest miRNA
hsa-let-7a-1/Upstream/1652596; hsa-mir-12126/Downstream/4382854;
Upstream sequence
catttgaattttatttcagaaatgaagcacttctaggtgatggatgataaagttcaggatgtggccctgggagcttgtgtgtcaaagtgaaatggagcta
Downstream sequence
CCCCATGGTTTCAGAATACACTAATGAAAGAAACCACACTGTGGAGACACTTCCAAAATCCAGAGGATATGTGCCTCCCATTGACAGCAGGGGATGGAGT
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).