Basic Information
VIS ID
TVIS10004757
Fusion event
HBV-LINC01503 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2138
Orient
-
Integrated sequence
CATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGGCCACCTGGGTGGGAAGTAATTTGGAAGACCCAG| |CATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGAAGAGA
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
132109434/129347155 (Hg38)
End
132109434/129347155 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC01503
Nearest miRNA
hsa-let-7a-1/Upstream/954441; hsa-mir-12126/Downstream/522450;
Nearest TSS
ENST00000422679/Upstream/5312; ENST00000439014/Downstream/91061;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/9818, chr9-CpG: 31/Downstream/4896
Upstream sequence
tttatagcagtgtgagaatggactaaaacaAGATGCCTAAAAGATAACTACGTGGTTAATGGCTAGCATTTAAGTGAAAATGTTAATGTACTCCTCAGAT
Downstream sequence
gtgtgtatgtgtgtgtgtgtgtgtgtgtatatatatatatttattattattattatttttttttttgtagagaccggattttgccatgttggccaggctg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate