Basic Information
VIS ID
TVIS10004759
Fusion event
HBV-chrY integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1805
Orient
+
Integrated sequence
CTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chrY
Cytoband
q11.222
Reference genome
GRCh37/hg19
Start
20541521/18379635 (Hg38)
End
20541521/18379635 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12120/Upstream/4900369;
Nearest TSS
ENST00000430575/Upstream/53382; ENST00000510613/Downstream/25411;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/33069, chrY-CpG: 21/Downstream/7778
Nearby gene
FAM41AY2(+6946) ;
Upstream sequence
gcccattggatataaaccaatgcctgggtttatatcccaatcactgtccctccccctgtgctctcaggtgatatatgatttgactatttctttgtctcct
Downstream sequence
aaatataaataaaaatCTCATGTTTCTAACAAAATTTCTTTTGAATATCAATTGTATCAACTTGCATATTAACTATAATCATTTTGTTTACTTTATATCT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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