Fusion event
HBV-chrY integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
AGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACT| |GTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTT
End
20446038/18284152 (Hg38)
Nearest miRNA
hsa-mir-12120/Upstream/4804886;
Upstream sequence
GAAATAGTAAAGAGGTATAAGTTGTTTAGAACATTTTATTTTAAAATAACATGAAAGTCATGCATATATGGTCAGTCCTAAGTCCTTTTCATGTTATTTG
Downstream sequence
TTTTAAATATCCTAATATTTCATTTATAGTAGTTTCTGTCTCGTATTTGTGTATTGGTAAAAATTGTATTAGAAGAAAGAGGGCTTAAGACAACAATATT
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).