Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004761
Fusion event
HBV-DHDDS integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1847
Orient
-
Integrated sequence
GGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCAT| |GTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACT
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
Start
End
26784061/26457570 (Hg38)
Orient
-
Location type
Intron
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-6788-5p ; hsa-mir-1273h-5p ; hsa-mir-30c-2-3p ; hsa-mir-4316 ; hsa-mir-30c-1-3p ; hsa-mir-4710 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6804-5p ; hsa-mir-6089 ; hsa-mir-5008-5p
Nearest miRNA
hsa-mir-12136/Upstream/551116; hsa-mir-101-1/Downstream/96972;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/25205, chr1-CpG: 159/Downstream/14305
Upstream sequence
aataaataaataaataaataaataCCTTATGTATCAGAACATGTCAAAAAAGGCAAAAAATAAAAAAGAGAAAAGAATTTTACATTGTATTCTCTAAAAA
Downstream sequence
AAAAAAAAAAAAAGAAATACCTTATGTAGTTGTGAAGATTTAAATTCattcattaatttagcaaacattttttgagggccttctgtgtAGTATTGGCTAG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).