Basic Information
VIS ID
TVIS10004766
Fusion event
HBV-LOC101929230 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1806
Orient
+
Integrated sequence
TTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCAC| |CAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGAC
Host Sequence
Chromosome
chr2
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
21871448/21648576 (Hg38)
End
21871448/21648576 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101929230
Nearest miRNA
hsa-mir-3125/Upstream/2300071; hsa-mir-10b/Downstream/3680064;
Nearest TSS
ENST00000437798/Upstream/12267; ENST00000419013/Downstream/926;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/604487, chr2-CpG: 256/Downstream/1736282
Upstream sequence
TGTCTTTCTTTCAGAATGTGATGGGTCTTCTGGGTGTGATATTTGCATGAATCCTTAGAGAAGGAAACTTGAAAAGATATAAAGAAAACTTGTAAATAAC
Downstream sequence
TGACTGAAAGAAAGCAAACTTCTTTACTGCTACTCTTCATGGTGCCTTCCATGTGGCTCCTAGGGATATCTTAGGAACCAGGCAAGATGCAGAGGAACAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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