Basic Information
VIS ID
TVIS10004768
Fusion event
HBV-chr2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
2888
Orient
-
Integrated sequence
AACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGGAC| |GAATCTTTCTGTTCCCAATCCTCTGGGATTCTTTCCCGATCACCAGTTGGACCCTGCGTTCGGAGCCAACTCAAACAATCCAGATTGGGACTTCAACCCC
Host Sequence
Chromosome
chr2
Cytoband
q37.3
Reference genome
End
243152526/242183478 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-10b/Upstream/705496;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/94067, None/Downstream
Nearby gene
RPL23AP88(-7793) ;
Upstream sequence
NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccct
Downstream sequence
aaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctgaccctgaccctgaccctgaccctgaccccgaccccgaccccgacc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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