Fusion event
HBV-FN1 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTT
End
216300004/215435281 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10b/Upstream/1677122; hsa-mir-1244-1/Downstream/2465232;
Upstream sequence
AAAGAGGTCTGAACCAATTACATCTCTTCCAAGTTAGTTAGAAACAAGACAGCTATTTCAATACCCCCTTTCCACCCCCATGTTGAAAATATTTGACCAA
Downstream sequence
TTATTTAACAGAAGGAAATAAGTAGCAGTAAGGACCACACTAATCCCAGACGGAAAATTTATAGACATGCATCATTTTTCTCTTTAAAGGCAAGTTTTGG
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).