Fusion event
HBV-chr1 integration
Detection method
PCR and Ultra-deep sequencing
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Integrated sequence
GGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAA| |GCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCT
End
247986249/247822947 (Hg38)
Nearest miRNA
hsa-mir-101-1/Upstream/620887; hsa-mir-3124/Downstream/1003430;
Upstream sequence
aTCAAGAAAAGATGCAGAGGTTTTGAGGGATCTCAAACACAAATTTTTTCCAGAATTCAGTTTCCCCAGAAGGGAAGCATATAAAATATTTGGCCAGCTG
Downstream sequence
AATGTAAGACTGTCACTTGAATTTTGTAAAATAAAATTAAGGGTTTCAAAATATATAATGTCTGTATTCTCTAAAGGACCCTATTGATTTGTATTCCTTA
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).