Basic Information
VIS ID
TVIS10004786
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1875
Orient
-
Integrated sequence
GGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAA| |GCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCT
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
End
247986249/247822947 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-101-1/Upstream/620887; hsa-mir-3124/Downstream/1003430;
Nearby gene
OR14A16(-7218) ; HSD17B7P1(+4517) ;
Upstream sequence
aTCAAGAAAAGATGCAGAGGTTTTGAGGGATCTCAAACACAAATTTTTTCCAGAATTCAGTTTCCCCAGAAGGGAAGCATATAAAATATTTGGCCAGCTG
Downstream sequence
AATGTAAGACTGTCACTTGAATTTTGTAAAATAAAATTAAGGGTTTCAAAATATATAATGTCTGTATTCTCTAAAGGACCCTATTGATTTGTATTCCTTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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