Basic Information
VIS ID
TVIS10004790
Fusion event
HBV-chr7 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1811
Orient
-
Integrated sequence
AGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCA| |CCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGA
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
74125223/74710892 (Hg38)
End
74125223/74710892 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA7J
Target gene
GTF2I ; LOC101926943
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-21-5p ; hsa-mir-1229-3p ; hsa-mir-10a-3p ; hsa-mir-484 ; hsa-mir-23b-3p ; hsa-mir-99a-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-580-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-3121-3p
Nearest miRNA
hsa-mir-10525/Upstream/114866; hsa-mir-10399/Downstream/1204305;
Nearest TSS
ENST00000635602/Upstream/5715; ENST00000484840/Downstream/5720;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/52140, chr7-CpG: 124/Downstream/77097
Upstream sequence
TGTTCAGATTTACAACAGTTCTAAGAAGCTGCATCTCAGTTACTCAGAGGGTAAAATGGAACCAAATAATCACCTCTACACCCTAACTGAGAGGAGGAAT
Downstream sequence
TTGTCTTTTCAAAGACGTAAAGTCTTTACTTAAAATAAATATGCATTGCTGTATTTATAGGGAGGGCAGAGAGGATTTCCCTACACAATCTAGCTGAAAG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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