Basic Information
VIS ID
TVIS10004798
Fusion event
HBV-chr20 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1818
Orient
+
Integrated sequence
TTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTAT
Host Sequence
Chromosome
chr20
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
31205660/32617858 (Hg38)
End
31205660/32617858 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/380011; hsa-mir-1-1/Downstream/1431261;
Nearest TSS
ENST00000382410/Upstream/30379; ENST00000456297/Downstream/33901;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/32020, chr20-CpG: 60/Downstream/125293
Nearby gene
NOL4L-DT(-8965) ;
Upstream sequence
ggtgacttagcccaaggatgatcggcttagcctgtgatgctgacaggactgaaacctagggcctctgcctctaaatctcagttcatttgactCTGTCTGT
Downstream sequence
GTCCCTGACAGGCCTCAGCCTGGGACAGGGTGGGCAACGAAGAGGCCAGAGCAGCTGGGTCCCAGGAAATGAGCACtccattggggctcgaacccaggac
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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