Basic Information
VIS ID
TVIS10004799
Fusion event
HBV-chr20 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2376
Orient
-
Integrated sequence
TTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAG| |AACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGG
Host Sequence
Chromosome
chr20
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
35170199/36541796 (Hg38)
End
35170199/36541796 (Hg38)
Orient
-
Location type
Intron
Target gene
DLGAP4-AS1 ; MYL9
miRNAs that regulate target gene
hsa-mir-663a ; hsa-mir-6864-5p ; hsa-mir-3192-3p ; hsa-mir-6747-5p ; hsa-mir-3179 ; hsa-mir-7515 ; hsa-mir-3151-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-3936 ; hsa-mir-6782-5p ; hsa-mir-223-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/1087699; hsa-mir-1-1/Downstream/1974767;
Nearest TSS
ENST00000382410/Upstream/299; ENST00000558028/Downstream/31188;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/112, chr20-CpG: 199/Downstream/31124
Junction sequence
A
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate