Basic Information
VIS ID
TVIS10004804
Fusion event
HBV-LINC00971 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2807
Orient
-
Integrated sequence
TGAACATGCAGTTAATCATTACTTCAAAACTAGGCATTATTTACATACTCTGTGGAAGGCTGGCATTCTATATAAGAGAGAAACTACACGCAGCGCTTCA| |TTTTGTGGGTCACCATATTCTTGGGAACAAGAGCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGGACGAATCTTTCTGTTCCCAAT
Host Sequence
Chromosome
chr3
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
84718506/84669355 (Hg38)
End
84718506/84669355 (Hg38)
Orient
+
Location type
Exon
Target gene
LINC00971
Nearest miRNA
hsa-let-7g/Upstream/5161386; hsa-mir-12124/Downstream/716355;
Nearest TSS
ENST00000440867/Upstream/2683203; ENST00000488348/Downstream/200220;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1861262, chr3-CpG: 48/Downstream/289778
Upstream sequence
GTCTGAGAATTATTGCCATGTCTGCAGGCCAGAGATAAAGCAGGGAACGTGGCGACGGACTACAGGCCTTTCAGTAAACTCTGCAGTACCTCACTAAACA
Downstream sequence
atataatacatatctaatattttattatatatgtaatatattttatacatctaatatatattatatatgcatacacatctaatatataacatatatacat
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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