Basic Information
VIS ID
TVIS10004812
Fusion event
HBV-chrX integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2839
Orient
+
Integrated sequence
GGCATTATTTACATACTCTGTGGAAGGCTGGCATTCTATATAAGAGAGAAACTACACGCAGCGCTTCATTTTGTGGGTCACCATATTCTTGGGAACAAGA| |GCTACAGCATGGGAGGTTGGTCTTCCAAACCTCGACAAGGCATGGGGACGAATCTTTCTGTTCCCAATCCTCTGGGATTCTTTCCCGATCACCAGTTGGA
Host Sequence
Chromosome
chrX
Cytoband
p22.32
Reference genome
GRCh37/hg19
Start
5246889/5328848 (Hg38)
End
5246889/5328848 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-3690-1/Upstream/2719594; hsa-let-7f-2/Downstream/1055058;
Nearest TSS
ENST00000429181/Upstream/695276; ENST00000217961/Downstream/397109;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1407826, chrX-CpG: 21/Downstream/564118
Upstream sequence
gtaatgcaaacgatggggagtggctttaaatatcagtgaaactttgcctgctccacgctcacctcctgctatgcagcccagttcctaagagaccacagaa
Downstream sequence
tctgcaattttgctttttagattgtggattaactgtcttcctcattgcttttgttctgtaaatgactagaagcgaccagacatcagacttcccctttccc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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