Basic Information
VIS ID
TVIS10004813
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1151
Orient
+
Integrated sequence
TGATGCCTTTATATGCATGTATACAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAAACAATATCTGCACCTTTACCCCGT| |TGCCCGGCAACGGTCAGGTCTCTGCCAAGTGTTTGCTGACGCAACCCCCACTGGATGGGGCTTGGCCATAGGCCATCGGCGCATGCGTGGAACCTTTGTG
Host Sequence
Chromosome
chr1
Cytoband
p36.32
Reference genome
GRCh37/hg19
Start
4711068/4651008 (Hg38)
End
4711068/4651008 (Hg38)
Orient
+
Location type
Promoter
Fragile sites / regions
FRA1A
Nearest miRNA
hsa-mir-12136/Upstream/1090218; hsa-mir-101-1/Downstream/1211664;
Nearest TSS
ENST00000473358/Upstream/79460; ENST00000466761/Downstream/3724;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/489396, chr1-CpG: 317/Downstream/2921
Nearby gene
AJAP1(+3767) ;
Nearest cancer related gene
AJAP1(TSG, +3767) ;
Upstream sequence
GATAGGAGAGTCAGGGAAGACACTCCTGTGAATGCTTTCAAGAAACTTATAATAATTTTAATCAGCATTTTCCCTTCCATTTAAAATCACAAACTTAGCT
Downstream sequence
ACTTAATCAAATGTCATGGTTAAGACACATTTACCTCCTTGGGAGAAAAATGAACAATGGCAGCTCAATTTGGCTTTGGATGGGTTTTAAAAATAGTCAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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