Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004821
Fusion event
HBV-DAB1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1814
Orient
+
Integrated sequence
CTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCA| |TGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCC
Host Sequence
Chromosome
chr1
Cytoband
p32.2
Reference genome
Start
End
57808225/57342553 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-12136/Upstream/2116830; hsa-mir-101-1/Downstream/2390674;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/696989, chr1-CpG: 222/Downstream/79738
Upstream sequence
gtggatgctcaataaacgcttgctaagggaaAAACAAAAAAATAAAAGCAATAAGCAACAACTCCCTATCTAAGACAGGAATATTATTTGCAGGAAAGCA
Downstream sequence
ATTCAAGGATGATCATACTAATAAGTGCTCTtgtgtccaaaattggtgggttcttggtctcactgacttcaagaatgaagacgcggaccctggcagtgag
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).