Basic Information
VIS ID
TVIS10004831
Fusion event
HBV-MINDY1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
841
Orient
-
Integrated sequence
GATGATGTGGTATTGGGGGCCAAGTCTGTACAACATCTTGAGTCCCTTTTTACCTCTATTACCAATTTTCTTTTGTCTTTGGGTATACATTTGAACCCTA| |ATAAAACCAAACGTTGGGGCTACTCCCTTAACTTCATGGGATATGTAATTGGAAGTTGGGGTACTTTACCACAGGAACATATTGTACGGAAACTCAAGCA
Host Sequence
Chromosome
chr1
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
150980836/151008360 (Hg38)
End
150980836/151008360 (Hg38)
Orient
+
Location type
Promoter FAM63A,exon
Fragile sites / regions
FRA1F
Target gene
MINDY1
miRNAs that regulate target gene
hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-4433a-3p ; hsa-mir-6504-3p ; hsa-mir-4433b-3p ; hsa-mir-4700-3p ; hsa-mir-1303 ; hsa-mir-5096 ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-483-5p ; hsa-mir-1297 ; hsa-mir-1976 ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-3653-5p ; hsa-mir-4279 ; hsa-mir-4465 ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-6513-3p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6778-3p ; hsa-mir-8062
Nearest miRNA
hsa-mir-101-1/Upstream/456346; hsa-mir-1182/Downstream/537436;
Nearest TSS
ENST00000473358/Upstream/1489; ENST00000467771/Downstream/5;
Nearest CpG islands
chr1-CpG: 42/Target, None/Upstream, None/Downstream
Upstream sequence
GAACGACTGATCCCTCAGAAAACAATCCTTCCCTCGGTTGCTAGGGACATTGCGGAGTTGCGGGACTACGTTTCCCACGTCGCCCCACGCCACGCCCCCT
Downstream sequence
TGGCCTCGCCGGAAAGACGTCCCAGGAGCCTCTGGGCGTAGAGCCCCGCCTCCGCCGCTGGGGGCGGGGCGACGCCGGACTCCGGAGCGCCCGCTTACGC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate