Basic Information
VIS ID
TVIS10004843
Fusion event
HBV-chr1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
378
Orient
-
Integrated sequence
TAGGGGGAGCACCCACGTGTCCTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGCTATCGCTGGAT| |GTGTCTGCGGCGTTTTATCATATTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTTGTCCT
Host Sequence
Chromosome
chr1
Cytoband
q43
Reference genome
GRCh37/hg19
Start
243663213/243499911 (Hg38)
End
243663213/243499911 (Hg38)
Orient
+
Location type
Exon AKT3,intron AKT3,Exon
Target gene
AKT3 ; SDCCAG8
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-519d-3p ; hsa-mir-335-5p ; hsa-mir-29c-3p ; hsa-mir-124-3p ; hsa-mir-124-3p ; hsa-mir-146b-5p ; hsa-mir-2054 ; hsa-mir-297 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-6134 ; hsa-mir-7854-3p ; hsa-mir-4725-5p ; hsa-mir-545-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-4781-3p ; hsa-mir-3976 ; hsa-mir-6856-5p ; hsa-mir-646 ; hsa-mir-6758-5p ; hsa-mir-595 ; hsa-mir-503-5p ; hsa-mir-497-5p ; hsa-mir-195-5p ; hsa-mir-6838-5p ; hsa-mir-424-5p ; hsa-mir-15b-5p ; hsa-mir-374a-3p ; hsa-mir-361-5p ; hsa-mir-569 ; hsa-mir-222-3p ; hsa-mir-221-3p ; hsa-mir-873-5p ; hsa-mir-7-5p ; hsa-mir-552-5p ; hsa-mir-5582-5p ; hsa-mir-708-3p ; hsa-mir-548an ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-29b-1-5p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-20b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/153656; hsa-mir-3124/Downstream/3702056;
Nearest TSS
ENST00000473358/Upstream/12096; ENST00000439849/Downstream/45621;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/10450, chr1-CpG: 166/Downstream/349499
Upstream sequence
GATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGC
Downstream sequence
TGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATG
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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