VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10004853

Fusion event

HBV-ANAPC16 integration

Validated

No

Detection method

PCR and Ultra-deep sequencing

Data source

Curated

Sample type

Nontumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

29861854

Virus Sequence

Virus name

HBV

Reference genome

AP011098

Start

1832

Orient

+

Integrated sequence

GGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCT| |GCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGC

Host Sequence

Chromosome

chr10

Cytoband

q22.1

Reference genome

GRCh37/hg19

Start

73979120/72219362 (Hg38)

End

73979120/72219362 (Hg38)

Orient

-

Location type

Promoter ANAPC16,intron

Target gene

ANAPC16

miRNAs that regulate target gene

hsa-mir-125b-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-155-5p ; hsa-mir-6514-3p ; hsa-mir-6811-3p ; hsa-mir-125a-5p ; hsa-mir-488-3p ; hsa-mir-605-5p ; hsa-mir-670-5p ; hsa-mir-4319 ; hsa-mir-4324 ; hsa-mir-5186 ; hsa-mir-510-3p ; hsa-mir-4715-3p ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-4732-3p ; hsa-mir-345-3p ; hsa-mir-186-3p ; hsa-mir-4733-5p ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-606 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-4443 ; hsa-mir-6515-5p ; hsa-mir-7977 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6847-3p ; hsa-mir-214-5p ; hsa-mir-383-3p ; hsa-mir-4284 ; hsa-mir-24-3p ; hsa-mir-4684-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-6827-3p ; hsa-mir-340-3p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-6771-3p

Nearest miRNA

hsa-mir-1265/Upstream/428562; hsa-mir-107/Downstream/501667;

Nearest TSS

ENST00000439456/Upstream/2228; ENST00000470481/Downstream/3771;

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/3005, chr10-CpG: 20/Downstream/41653

Junction sequence

CCTTTCCTCACATTTCA

* Color: Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence

Reference

Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).