Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004854
Fusion event
HBV-ANAPC16 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
403
Orient
-
Integrated sequence
CCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGCTATCGCTGGATGTGTCTGCGGCGTTTTATCATATTC| |CTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTACCAAGGTATGTTGCCCGTTTGTCCTCTACTTCCAGGAACATCAACTACCA
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
Start
End
73979466/72219708 (Hg38)
Orient
+
Location type
Promoter ANAPC16,intron
Target gene
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-155-5p ; hsa-mir-6514-3p ; hsa-mir-6811-3p ; hsa-mir-125a-5p ; hsa-mir-488-3p ; hsa-mir-605-5p ; hsa-mir-670-5p ; hsa-mir-4319 ; hsa-mir-4324 ; hsa-mir-5186 ; hsa-mir-510-3p ; hsa-mir-4715-3p ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-4732-3p ; hsa-mir-345-3p ; hsa-mir-186-3p ; hsa-mir-4733-5p ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-3613-3p ; hsa-mir-606 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-4443 ; hsa-mir-6515-5p ; hsa-mir-7977 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6847-3p ; hsa-mir-214-5p ; hsa-mir-383-3p ; hsa-mir-4284 ; hsa-mir-24-3p ; hsa-mir-4684-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-6827-3p ; hsa-mir-340-3p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-6771-3p
Nearest miRNA
hsa-mir-1265/Upstream/428908; hsa-mir-107/Downstream/501321;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/3351, chr10-CpG: 20/Downstream/41307
Upstream sequence
tgcctgtagtcccaactactcgggagactgaggtgagaggataacttgtacccaggaggtcaaggctggagttagccaggatagtgccactgcattccag
Downstream sequence
cctgggaaacatagcgacactctgtctccaaacaaaataaaaaataaaaTGTCATTAATCAATTTGCATTTTTGCTGACAGTCTAGTTATAATAGCTGTT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).