Basic Information
VIS ID
TVIS10004856
Fusion event
HBV-LRMDA integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2205
Orient
-
Integrated sequence
CCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGTG| |GTTTCACATTTCCTGTCTTACTTTTGGAAGAGAAACTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCA
Host Sequence
Chromosome
chr10
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
78204875/76445117 (Hg38)
End
78204875/76445117 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA10D
Target gene
LRMDA
Nearest miRNA
hsa-mir-1265/Upstream/892564; hsa-mir-107/Downstream/9819577;
Nearest TSS
ENST00000439456/Upstream/6342; ENST00000493194/Downstream/19697;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/332570, chr10-CpG: 220/Downstream/1191220
Upstream sequence
TGTGCCTATGAAGGACAAAGCGCGGTGCAAAGCACTGTGGGGAATACTTGGTAGATTAAGACACAGGTCTTCCTCTCAAGGATCTAGAGGGCATGTAGTT
Downstream sequence
ATTAAAAGCTGTTAACTATCCCAGGAATGCCTACCCTTCTCCATGATTTGGTAGCTGATATAGGATAATTTGCCCCTGGATTTTGTGAATAATAAAGAAC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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