Basic Information
VIS ID
TVIS10004866
Fusion event
HBV-LOC107984361 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
289
Orient
-
Integrated sequence
GCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAGCA| |CCCACGTGTCCTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAATTTGTCCTGGCTATCGCTGGATGTGTCTGCGGC
Host Sequence
Chromosome
chr11
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
87510289/87799397 (Hg38)
End
87510289/87799397 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11F
Target gene
LOC107984361
Nearest miRNA
hsa-mir-10392/Upstream/1520999; hsa-let-7a-2/Downstream/377105;
Nearest TSS
ENST00000527297/Upstream/79986; ENST00000532849/Downstream/250709;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/761346, chr11-CpG: 45/Downstream/375678
Upstream sequence
tacgtttttgcagtggctggtaccagttttctctttccatgtttagtgcttccttcaggagctcttgtaaggcgggcctggtggtgacaaaatctctcag
Downstream sequence
catttgtttgtctgtaaaggattttatttctccttcgcttatgaagcttagtttggctggatatgaaattctggtttgaaaattctttcctttaagaatg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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