Basic Information
VIS ID
TVIS10004868
Fusion event
HBV-APOA1-AS integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1746
Orient
+
Integrated sequence
GTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGG| |AGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCA
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
116708951/116838235 (Hg38)
End
116708951/116838235 (Hg38)
Orient
-
Location type
Promoter
Fragile sites / regions
FRA11G ; FRA11B
Target gene
APOA1-AS
Nearest miRNA
hsa-mir-10392/Upstream/3388147; hsa-let-7a-2/Downstream/1805765;
Nearest TSS
ENST00000527297/Upstream/285; ENST00000442124/Downstream/10903;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/2041, chr11-CpG: 117/Downstream/259587
Upstream sequence
TAAACCTGGGGAGAGGGGAGAGCCCTCCgtggctcccagactgaggtttcggagacctcttgcatttcaaaacactccagagatcaattcggagctgcca
Downstream sequence
acttttaattttgtcatgtaaagatattgtccgcctccaaaaaaccctcaccatctacagtgaccatcacttcaaaaaggaaaggctttaacaaaaaagg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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