Basic Information
VIS ID
TVIS10004869
Fusion event
HBV-chr11 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1818
Orient
+
Integrated sequence
TTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTAT
Host Sequence
Chromosome
chr11
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
124040941/124170234 (Hg38)
End
124040941/124170234 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-2/Upstream/788722; hsa-mir-3167/Downstream/2818224;
Nearest TSS
ENST00000527297/Upstream/52739; ENST00000318666/Downstream/13111;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/428397, chr11-CpG: 44/Downstream/452534
Upstream sequence
gaagctgcagaccttcgcggtgagtgttacagctcataaaagcagtgtggacccaaagagtaagcagtagcaagatttattgcaaagagcagaagaacaa
Downstream sequence
agcttccacagtgtggaaggggaccccagcagcttgccactgctggctcaggcagcctggttttattctcttatctggccccacccacatcctgctgatt
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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