Basic Information
VIS ID
TVIS10004872
Fusion event
HBV-chr12 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2105
Orient
-
Integrated sequence
GCTCTGTATCGGGAGGCCTTAGAGTCTCCGGAACATTGTTCACCTCACCATACAGCACTCAGGCAAGCTATTCTGTGTTGGGGTGAGTTGATGAATCTGG| |CCACCTGGGTGGGAAGTAATTTGGAAGACCCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGTG
Host Sequence
Chromosome
chr12
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
73605675/73211895 (Hg38)
End
73605675/73211895 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/3627072; hsa-mir-1178/Downstream/6207362;
Nearest TSS
ENST00000382841/Upstream/5060; ENST00000551387/Downstream/548794;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/938124, chr12-CpG: 38/Downstream/1325817
Nearby gene
LINC02444(-3578) ;
Upstream sequence
ATTTTAGAATAAAAGGAAAATCTAAATTTTTATTTCTTACCAGAGTATATGATAATGGAGaaaattataaaaatcataattaattaaaCAGCTGCTTAAA
Downstream sequence
TTCAACCCATGAGTCTATTAGAATAAAATAAAATTTGTTGAGGACATGTTAGTGCATGGCTACCACTGGCAATCAATTTCACATACTATTTCtttctaaa
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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