Basic Information
VIS ID
TVIS10004873
Fusion event
HBV-chr12 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1814
Orient
+
Integrated sequence
CTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCA| |TGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCC
Host Sequence
Chromosome
chr12
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
73605695/73211915 (Hg38)
End
73605695/73211915 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/3627092; hsa-mir-1178/Downstream/6207342;
Nearest TSS
ENST00000382841/Upstream/5080; ENST00000551387/Downstream/548774;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/938144, chr12-CpG: 38/Downstream/1325797
Nearby gene
LINC02444(-3598) ;
Upstream sequence
TCTAAATTTTTATTTCTTACCAGAGTATATGATAATGGAGaaaattataaaaatcataattaattaaaCAGCTGCTTAAATTCAACCCATGAGTCTATTA
Downstream sequence
GAATAAAATAAAATTTGTTGAGGACATGTTAGTGCATGGCTACCACTGGCAATCAATTTCACATACTATTTCtttctaaatttattgaggtatatttgac
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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