Basic Information
VIS ID
TVIS10004876
Fusion event
HBV-chr12 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2329
Orient
-
Integrated sequence
TGGAAGAGAAACTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTT| |CCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTC
Host Sequence
Chromosome
chr12
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
77665075/77271295 (Hg38)
End
77665075/77271295 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/7686472; hsa-mir-1178/Downstream/2147962;
Nearest TSS
ENST00000382841/Upstream/42602; ENST00000552736/Downstream/53346;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/205133, chr12-CpG: 38/Downstream/1532989
Upstream sequence
TATAAAGCCAGTGACAAGGAATTTGAATTTTATTGTGCTTTTATTTTATAAATTAAAGGACATTATTATTTGGATAGTGCTTTGGAAAACATGACTTTAT
Downstream sequence
TTTGAAATGTTTTTTTTTTCTACAAAATGTTGAGTTAGCAGGTTTATGTGGCAATAGAGAAACAGAAAAATAATGCAATGAAGAGCCAGCTATCATTGAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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