Basic Information
VIS ID
TVIS10004880
Fusion event
HBV-LOC105369912 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1923
Orient
-
Integrated sequence
TTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGA| |ATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAGATCTCCTCGACACCGCCTCTGCTCTGTATCGGGAGGCC
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
94384917/93991141 (Hg38)
End
94384917/93991141 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105369912
Nearest miRNA
hsa-let-7i/Upstream/7245992; hsa-mir-1178/Downstream/570648;
Nearest TSS
ENST00000382841/Upstream/46100; ENST00000546733/Downstream/157582;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/313262, chr12-CpG: 31/Downstream/110916
Upstream sequence
TTCCCAAGGCTCTCATGGATGTATGAGGACCAGTCAACAGCGAAGGGTGGCTGACTGTGACAGAGCCAGCAAGAGAGGATTCAGTCACAGAGAAAAAAAT
Downstream sequence
GCAGGCCCCCAGCCAGGGTCCTCCCGCAAAGTATGACAATTCAGAACTACTGGGGATGATACAGACAACATTCAGCCTCCAGTGTGTGTTCCTGTCTCTC
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate