Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004883
Fusion event
HBV-TMEM132D integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1821
Orient
+
Integrated sequence
TTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAA
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
End
129705013/129220468 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
Target gene
Nearest miRNA
hsa-let-7i/Upstream/926290; hsa-mir-6763/Downstream/3361529;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/275170, chr12-CpG: 26/Downstream/82722
Upstream sequence
AGGTGCATCCAGTTGGCAGGGACTGGATCGCAAGCCCATATACCCTCACAGACACTTTGCTGCCTTTCAGGAAAATCTGAGCCAAGTAGATTTTTGGAAA
Downstream sequence
GTACCTTGTGGGGATGAGATTTACACAGTGGAGAGAGCTCTCAAAGCTCAGAGAGAGTATTTTGTGGGCAGCTGCAACAGTTTTCCACTACATGTGTCAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).