Basic Information
VIS ID
TVIS10004890
Fusion event
HBV-chr13 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1370
Orient
+
Integrated sequence
CTGCGGAACTCCTAGCAGCTTGTTTTGCTCGCAGCCGGTCTGGAGCAAAACTTATCGGGACTGACAACTCTGTTGTCCTCTCTCGGAAATACACCTCCTT| |CCCATGGCTGCTCGGGTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGC
Host Sequence
Chromosome
chr13
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
66175706/65601574 (Hg38)
End
66175706/65601574 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA13B
Nearest miRNA
hsa-mir-1297/Upstream/4401694; hsa-mir-1267/Downstream/364756;
Nearest TSS
ENST00000623511/Upstream/1525563; ENST00000437777/Downstream/264600;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1757028, chr13-CpG: 92/Downstream/1628802
Upstream sequence
tggccCAACTAAATAATTTTTTAAAACATCCTTTTAGAAGTTGGTCTGTATAAAATGAGTTTATGTACAAAACATTTATTTCATTTTCTCCTAAAGCTTC
Downstream sequence
ATTTTATCTTAAATTATTAACAAAGTCCATAATTTTAATTTGAAATGGAATTAAAAGAAATGTCAGGCTAATAATTGTAATTATATATTTTCTATTTTAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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