Basic Information
VIS ID
TVIS10004896
Fusion event
HBV-LOC105378178 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1805
Orient
+
Integrated sequence
CTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
49164103/48694900 (Hg38)
End
49164103/48694900 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105378178
Nearest miRNA
hsa-mir-208a/Upstream/933796; hsa-mir-1185-1/Downstream/1271499;
Nearest TSS
ENST00000550708/Upstream/203133; ENST00000557531/Downstream/382605;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/1018514, chr14-CpG: 30/Downstream/891032
Upstream sequence
TTTCTTTAGTAAGTGTTACAAATAAATAAAATGGCTCATGAGGTACCTGTAATCCAAAACATCCCAGATAAAAATGAAGAACACTTTTGTTTGGGATGAT
Downstream sequence
CCCACCATGAAATCCATAAGCATCAGTGTAAAACTAGACATATTCTATTGATTTCAATCAACCCGGTCTTTGCTGTTAAGTCACCTGTTAAGTATCAGTA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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