Basic Information
VIS ID
TVIS10004900
Fusion event
HBV-IGH integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1802
Orient
+
Integrated sequence
ATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGT| |TCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCAT
Host Sequence
Chromosome
chr14
Cytoband
q32.33
Reference genome
GRCh37/hg19
Start
106811661/106355735 (Hg38)
End
106811661/106355735 (Hg38)
Orient
-
Location type
Intronic
Target gene
IGH
Nearest miRNA
hsa-mir-1185-1/Upstream/496182; hsa-mir-5195/Downstream/495150;
Nearest TSS
ENST00000550708/Upstream/1031; ENST00000620337/Downstream/856;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/68493, chr14-CpG: 42/Downstream/43158
Upstream sequence
catggctgctgctgggacacatgggaggatccctgatggacaactgtgctcagcgaggcaccaatggccttgctggaCTTAGCTTGGACCACGGGGTCAT
Downstream sequence
CAGGGAAGCTCCATCAAACTCCCACCCTTCTCCAGCACTAGTTTTGGGTCTGGCATTGTGGGGTGGCAGTGTCTACAGACTCACGCGGCTCCTATGCATT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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