Basic Information
VIS ID
TVIS10004901
Fusion event
HBV-IGH integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1645
Orient
+
Integrated sequence
TCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAGGTCTTGCCCAA| |GGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGG
Host Sequence
Chromosome
chr14
Cytoband
q32.33
Reference genome
GRCh37/hg19
Start
107267808/106859593 (Hg38)
End
107267808/106859593 (Hg38)
Orient
-
Location type
Intronic
Target gene
IGH
Nearest miRNA
hsa-mir-1185-1/Upstream/8594;
Nearest TSS
ENST00000550708/Upstream/8176; ENST00000521105/Downstream/6302;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/46519, None/Downstream
Upstream sequence
cttggccaaaggttctcccactagcactatggaatcatgttccactcctcagggtgcatcagttattaccctatgacttggcagctaaaaggcccatacg
Downstream sequence
tttatagagtttacccccagagatcatctttgtcctattgcatgcatgtgttacaaaatactgaaagtgattcctgtgtgatatccactccaatcatgaa
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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