Basic Information
VIS ID
TVIS10004914
Fusion event
HBV-chr16 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2307
Orient
-
Integrated sequence
TTCACATTTCCTGTCTTACTTTTGGAAGAGAAACTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAA| |TGCCCCTATCTTATCAACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAA
Host Sequence
Chromosome
chr16
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
82276500/82242895 (Hg38)
End
82276500/82242895 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/631487; hsa-mir-11401/Downstream/446036;
Nearest TSS
ENST00000527434/Upstream/72599; ENST00000569455/Downstream/268001;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/72098, chr16-CpG: 100/Downstream/384151
Upstream sequence
ATAGCATAAAACTGCATAGGAACAGAACTCTGAGAGAGGTAGAAGACAATGACTCAGTTTGGAGGGGAGATACTTTTTTTTTTTTTAACCAGGCAAGGTC
Downstream sequence
ATGGGGTATGAAGTAGAGAAGGGGGATGGATCACAATTTTATCACTGGCGTgtatccatgacctccttggagtccaaagagaaacaccagaaagaaacat
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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