Basic Information
VIS ID
TVIS10004919
Fusion event
HBV-chr17 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2234
Orient
-
Integrated sequence
CCAGCATCCAGGGAATTAGTAGTCAGCTATGTCAATGTTAATATGGGCCTAAAAATCAGACAACTATTGTGGTTTCACATTTCCTGTCTTACTTTTGGAA| |GAGAAACTGTTCTTGAGTATTTGGTGTCTTTTGGAGTGTGGATTCGCACTCCTCCCGCTTACAGACCACCAAATGCCCCTATCTTATCAACACTTCCGGA
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
13049459/13146142 (Hg38)
End
13049459/13146142 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA17A
Nearest miRNA
hsa-mir-1253/Upstream/228800; hsa-mir-10226/Downstream/397387;
Nearest TSS
ENST00000595228/Upstream/50234; ENST00000580134/Downstream/160618;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/127893, chr17-CpG: 36/Downstream/350299
Upstream sequence
atgctactcagaacagcaccgactttaaaacttatgaattgcttatttctgaaattttccacttaatatatttggactgtgagtaactgaaactgagaaa
Downstream sequence
agcaaaaccgtggaaaagggaaaactgcATATGCTTTAGAAAATCTTTTTAGATTCATTGATATAATTAATTATGTTCATAGTTTTTAAAAAAGACTGAT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate