Basic Information
VIS ID
TVIS10004925
Fusion event
HBV-chr18 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
223
Orient
-
Integrated sequence
CTTCTCGAGGACTGGGGACCCTGCACAGAACATGGAGAGCACAACATCAGGATTCCTAGGACCCCTGCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACA| |AGAATCCTCACAATACCACAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAGCACCCACGTGTCCTGGCCAAAATTCGCAGTCCCCAA
Host Sequence
Chromosome
chr18
Cytoband
q23
Reference genome
GRCh37/hg19
Start
77933317/80175434 (Hg38)
End
77933317/80175434 (Hg38)
Orient
+
Location type
PARD6G,intron LOC100130522,intron
Target gene
PARD6G ; PARD6G-AS1
miRNAs that regulate target gene
hsa-mir-4279 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-150-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6814-5p ; hsa-mir-4446-5p ; hsa-mir-223-5p ; hsa-mir-4524a-3p ; hsa-mir-4740-3p
Nearest miRNA
hsa-mir-1-2/Upstream/7322052;
Nearest TSS
ENST00000575820/Upstream/27385; ENST00000615495/Downstream/8246;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/14728, chr18-CpG: 189/Downstream/70711
Upstream sequence
tcccatatcaaggtccggcttgtaacagtttctggggagggctctcttcccggcttacagacagctgccttcttcctgtatccccacgtggcagggagac
Downstream sequence
cgagatctctggtgcctcctcctctgcttacgacacagtctgattaggtcagggcttcgtccttacgatcttatttaaccttcatcaccccctaaagaca
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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