Basic Information
VIS ID
TVIS10004931
Fusion event
HBV-RNU6-66P integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1797
Orient
+
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr19
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
46790595/46287338 (Hg38)
End
46790595/46287338 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
RNU6-66P
Nearest miRNA
hsa-mir-10395/Upstream/268289; hsa-let-7e/Downstream/421944;
Nearest TSS
ENST00000633603/Upstream/56950; ENST00000524533/Downstream/9708;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/208152, chr19-CpG: 43/Downstream/9458
Junction sequence
AGGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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