Basic Information
VIS ID
TVIS10004939
Fusion event
HBV-LINC01122 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1761
Orient
+
Integrated sequence
ACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAA| |AGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACT
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
58917547/58690412 (Hg38)
End
58917547/58690412 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA2S
Target gene
LINC01122
Nearest miRNA
hsa-mir-1301/Upstream/2689617; hsa-mir-10b/Downstream/1696950;
Nearest TSS
ENST00000437798/Upstream/169659; ENST00000422793/Downstream/234190;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/261435, chr2-CpG: 103/Downstream/1770275
Junction sequence
CAAAGATCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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