Basic Information
VIS ID
TVIS10004941
Fusion event
HBV-LINC01122 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1822
Orient
-
Integrated sequence
TTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGTTCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAG
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
58961613/58734478 (Hg38)
End
58961613/58734478 (Hg38)
Orient
+
Location type
Intron
Fragile sites / regions
FRA2S
Target gene
LINC01122
Nearest miRNA
hsa-mir-1301/Upstream/2733683; hsa-mir-10b/Downstream/1652884;
Nearest TSS
ENST00000437798/Upstream/213725; ENST00000422793/Downstream/190124;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/305501, chr2-CpG: 103/Downstream/1726209
Upstream sequence
GGAATATTCCACTGAAGCTTTCTTATGTCCAGGTTTTCTTTTGATGACTAAGTGTGCCAGCAATGACTCTGACATCTACTGCTATGTCATGTGGGCTTTG
Downstream sequence
TTTACTGTATGAGCAATTTCTCAATGAAGAGAGGCATTTCAATTATTCCCAGTAGCTGTGTGCCTGTTGACACCTTGATGCTGTATAGGAAAGAGTGAGT
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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