Basic Information
VIS ID
TVIS10004945
Fusion event
HBV-LOC402096 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2481
Orient
-
Integrated sequence
CCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGAAACT| |TTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTGAGTGGCAAACTCCCTCCTTTCCTAACATTCATTTACAGGAGGACATTATTAATAGATG
Host Sequence
Chromosome
chr2
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
106990216/106373760 (Hg38)
End
106990216/106373760 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC402096
Nearest miRNA
hsa-mir-1285-2/Upstream/3941394; hsa-mir-10b/Downstream/2767730;
Nearest TSS
ENST00000437798/Upstream/179421; ENST00000643224/Downstream/94566;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/30690, chr2-CpG: 320/Downstream/92112
Upstream sequence
cctgggagttggaggttgcagtgagccaagagcacaccactgtactccagcttgggcaacagagtgagactgtctcaaaaaaaaaaaaaaaaaaaGGAGG
Downstream sequence
CTTGAGCGATTACTGATTGCCCTTTAGGCCTCTGGTCTGTTTGATGACAGCGGTAAGAAGGCACTTTATAAGTGTGTTGGAAGTTTGGGAAAGAGCAGAA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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