Basic Information
VIS ID
TVIS10004953
Fusion event
HBV-chr2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2423
Orient
+
Integrated sequence
ACACTTCCGGAAACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAA| |GATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTG
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
199693369/198828645 (Hg38)
End
199693369/198828645 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2I
Nearest miRNA
hsa-mir-10b/Upstream/9695534; hsa-mir-1244-1/Downstream/7954589;
Nearest TSS
ENST00000437798/Upstream/56289; ENST00000489557/Downstream/243146;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1023215, chr2-CpG: 315/Downstream/627134
Upstream sequence
aatgaattagaaaaaaagtattttaaaattcatatggaaccaaaaaagaggtcatataacaaggacaatcctaagcaaaaagaacaaagctggaggcatc
Downstream sequence
atgctacccaacttccaactatactacaaggctacagtaaccaaaacagcatggtactggtacaaaaacaggcacatagaccaatgaaatggagtagaaa
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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