Basic Information
VIS ID
TVIS10004962
Fusion event
HBV-chr20 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1390
Orient
-
Integrated sequence
TGTTTTGCTCGCAGCCGGTCTGGAGCAAAACTTATCGGGACTGACAACTCTGTTGTCCTCTCTCGGAAATACACCTCCTTCCCATGGCTGCTCGGGTGTG| |CTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGGCTCTACCGTCC
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
5596854/5616208 (Hg38)
End
5596854/5616208 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/1698637; hsa-mir-1-1/Downstream/1755400;
Nearest TSS
ENST00000382410/Upstream/5182; ENST00000378979/Downstream/134185;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/4979, chr20-CpG: 57/Downstream/295024
Nearby gene
GPCPD1(-5162) ;
Upstream sequence
acctcaggtgatctgctgcttcagcctcccaaagtgttgggattacaggagtgagccactgggcctggccAAGACAAGATCTTGTTCGgttgctgagact
Downstream sequence
atgggtggacatcaccatgcctggctaatttggggtatgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgttagagatgtagtctcactatgttgcc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
Curate