Basic Information
VIS ID
TVIS10004963
Fusion event
HBV-chr20 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
2506
Orient
-
Integrated sequence
ATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATCCCTTGGACTCATAAGGTGGGAAACTTTACTGGGCTTTATTCTTCTACTGT| |ACCTGTCTTTAATCCTGAGTGGCAAACTCCCTCCTTTCCTAACATTCATTTACAGGAGGACATTATTAATAGATGTCAACAATATGTGGGCCCTCTTACA
Host Sequence
Chromosome
chr20
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
10380687/10400039 (Hg38)
End
10380687/10400039 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA20B
Nearest miRNA
hsa-mir-103a-2/Upstream/3028347; hsa-mir-1-1/Downstream/249597;
Nearest TSS
ENST00000382410/Upstream/31263; ENST00000334534/Downstream/31883;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/181703, chr20-CpG: 71/Downstream/33589
Nearby gene
MKKS(+4741) ;
Upstream sequence
tatcctgaagaaataatcagggatatgggaaaacaatatatacagtatgttcactgcattgttgcatatattaacacaaaaattttgaaaacaacccaaa
Downstream sequence
ggtttactaataccaatttattaactaaattatggcataatctttataactaaaatttcttcaggcattaaaaatgatataatatattccatttaccctg
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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