Basic Information
VIS ID
TVIS10004966
Fusion event
HBV-chr20 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1497
Orient
+
Integrated sequence
CTGGATCCTGCGCGGGACGTCCTTTGTCTACGTCCCGTCGGCGCTGAATCCCGCGGACGACCCGTCTCGGGGCCGTTTGGGGCTCTACCGTCCCCTTCTT| |CATCTGCCGTTCCGGCCGACCACGGGGCGCACCTCTCTTTACGCGGTCTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTC
Host Sequence
Chromosome
chr20
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
11486642/11505994 (Hg38)
End
11486642/11505994 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA20B
Nearest miRNA
hsa-mir-103a-2/Upstream/856299; hsa-mir-1-1/Downstream/6964621;
Nearest TSS
ENST00000382410/Upstream/204469; ENST00000450368/Downstream/35653;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/831031, chr20-CpG: 37/Downstream/180880
Upstream sequence
atgattgttacctagaaaaccttgaaaacttatccaaaagactcctatatctgatttttaaaaattcagtaaagtctcaggttacaaaatcaatgtacac
Downstream sequence
aaattagcagcactgctatacaccaacaaggaccaagctgagaataaaatcaagaactcaatttattctacaacagctgctctctctctttctctctctc
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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