Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004967
Fusion event
HBV-MACROD2 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Start
1885
Orient
-
Integrated sequence
GGCATAAATTGGTCTGTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTT| |GGGTGGCTTTGGGGCATGGACATTGACCCGTATAAAGAATTTGGAGCTTCTGTGGAGTTACTCTCTTTTTTGCCTTCTGACTTCTTTCCTTCTATTCGAG
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
Start
End
15454036/15473391 (Hg38)
Orient
+
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-4469 ; hsa-mir-486-5p ; hsa-mir-660-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-618 ; hsa-mir-502-5p ; hsa-mir-4786-3p ; hsa-mir-1915-5p ; hsa-mir-6841-3p ; hsa-mir-153-5p ; hsa-mir-6808-3p ; hsa-mir-7973 ; hsa-mir-486-3p ; hsa-mir-4252 ; hsa-mir-4725-5p ; hsa-mir-6852-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-504-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/4823696; hsa-mir-1-1/Downstream/2997224;
Nearest CpG islands
Upstream sequence
TAGAGTATGGGGTGCTGAAGAGTATGTACAGACTAGGGTATAGAGTAGGCATTCAAAAATATTTGCACAGTGAAAGGGCTGGGATTATAAGAGGCAAACA
Downstream sequence
TCTACCATCAATCCTCTGTCAGTTTTAAAATCTGTCCACCAGATATCAGAGAAGAATAAAATTAGACTGGGTGAATGTCTGACCCATTTATCATCTATCA
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).