TIAM1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10004971
Fusion event
HBV-TIAM1 integration
Validated
No
Detection method
PCR and Ultra-deep sequencing
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
29861854
Virus Sequence
Virus name
HBV
Reference genome
AP011098
Start
1800
Orient
+
Integrated sequence
GCATACTTCAAAGACTGTTTGTTTAAGGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCT| |GTTCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCATGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
32653067/31280752 (Hg38)
End
32653067/31280752 (Hg38)
Orient
+
Location type
Intron
Target gene
TIAM1
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-31-5p ; hsa-mir-335-5p ; hsa-mir-744-5p ; hsa-mir-93-3p ; hsa-mir-769-3p ; hsa-mir-615-3p ; hsa-mir-221-3p ; hsa-let-7b-5p ; hsa-mir-10b-5p ; hsa-mir-329-3p ; hsa-mir-141-3p ; hsa-mir-10a-5p ; hsa-mir-342-3p ; hsa-mir-29c-3p ; hsa-mir-22-3p ; hsa-mir-182-5p
Nearest miRNA
hsa-let-7c/Upstream/905374; hsa-mir-3197/Downstream/2269910;
Nearest TSS
ENST00000624081/Upstream/119843; ENST00000433071/Downstream/63527;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/28686, chr21-CpG: 40/Downstream/62977
Upstream sequence
TTGATGGGGCTGAGAAGTCCCACTGCTCCACTCCTGTAATATTATTTAAGATGAAAATACGGTGTCAGAAATACTGTGTCCACAGCATTTAATCCTTGGC
Downstream sequence
TTTTCCAAAAATGTCTGCCAAACCAGAACTTTCTTTTTCACCTTCAAAGTGTCAAAGACACTTGGGGGTGGGGGGGCAGGggacagacacagtggctcat
Reference
Tu, T., et al. Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles. J Virol ,2018,92(11).
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